Researchers have identified that low blood levels of the peptide hormone are an indicator for good microcirculation that describes blood flow through the smallest vessels in the circulatory system and indicates an increased lifespan.
The researchers found that the perfusion of organs and muscles of the centenarians was as efficient as that in people who were 30 years younger.
Low blood levels of the peptide hormone Adrenomedullin (bio-ADM) are an indicator for such a good microcirculation.
Very low concentrations of this biomarker indicate a well-functioning endothelial and microcirculatory system allowing good blood perfusion of organs and muscles.
A good microcirculation is what makes marathon runners perform better at the same heart rate than the average man or woman on the street.
Study measured levels of the heart-function biomarker MR-proANP, as well as a marker for kidney function (penKid) and bio-ADM.
The study was designed to identify genetic and epigenetic factors contributing to longevity in Italy and in Okinawa (Japan).